Set in Mumbai, ‘Zindagi 50-50’ revolves around the lives of three women and their predicament. It has been said that, the way you asks question to your life, it answers you in the same manner. People pray to god for happiness, so that they can enjoy their life. 'Zindagi 50:50' is the same story of such question and answers. It's a story of Rupa (A Housewife), Madhuri (Prostitute) and Nainja (A Struggling Actress).

Madhuri (Veena Malik) is a sex worker, who knows she is the best in the business. She does not regret anything until she finds solace in Birju (Rajan Verma). Birju is married to righteous Rupa (Supriya Kumar) whose world revolves around her husband. Naina (Riya Sen) is a junior artist who aspires to be a lead heroine. "Zindagi 50:50" is the same story of such question and answers - It's a story of Rupa (A Housewife), Madhuri (Prostitute) and Nainja (A Struggling Actress). Rupa's husband, Birju (Auto Driver) has a dream of getting a house. To fulfill his dream, Rupa breaks all the limits of her life.

To complete her dream of house, CR Lele (Government Servant) pushes her in a dark side of her life, where she gets the house, but also gets a smirch on her respect. Zindagi 50:50 is a story of special dreams of a common man. And to fulfill those dreams, he has to struggle a lot, but sometimes they gets it easily and sometimes he has to lose everything, "Zindagi 50:50" has this same of losing and getting.