The film starts in London, 6 years ago. 3 robbers attempt to steal jewels from a building but are captured by the police. In the present, Batook Patel (Boman Irani), a wealthy and successful businessman, is shown disapproving marriage of his three beautiful daughters, Ganga (Jacqueline Fernandez), Yamuna (Lisa Haydon), and Saraswati (Nargis Fakhri), as he believes that the previous ladies in his family were doomed because of marrying.

One night, at a friend's bachelorette party, the girls reveal to their friend that secretly, they each have a boyfriend. Jamuna's boyfriend is Teddy (Riteish Deshmukh), who wants to be a racer. Saraswati's boyfriend is Bunty (Abhishek Bachchan), who wants to be a rapper. Ganga's boyfriend is Sandy (Akshay Kumar), who wants to own his own football club. Sandy suffers from split personality disorder, his other form being Sundi. Sandy learns that Sundi comes out whenever he hears the word "Indian", and his Dissociative Identity Disorder comes from being depressed about not having enough money to make a living. This is why, Sandy, seeing how successful Batook is, decided to date Ganga, who is also his doctor. When the girls tell their dad that they each have a boyfriend, Batook goes to his friend, Aakhri Pasta (Chunkey Pandey), who owns an Italian restaurant. Batook convinces Pasta to dress up as the family's fortune teller, Aakhri Aasta.

Aasta then claims that when Ganga's husband first steps foot into Batook's house, Jamuna's husband first sees Batook, or Saraswati's husband first speaks to Batook, Batook will have a heart attack. The girls, wanting to keep their boyfriends, have them fake disabilities. Sandy rides around in a motorized wheelchair. Teddy wears sunglasses and uses a cane, and claims he is blind. Bunty uses sign language and claims that he is mute. Batook decides to test the boys, by putting ants in Sandy's pants, having Teddy jump in an empty pool, and injuring Bunty to see if he screams, to which they pass. When Batook is out of the house, the boys reveal themselves to each other and decide not to tell on each other and split the money. At Pasta's restaurant, Batook reveals to Pasta that his daughters are actually the daughters of Urja Nagre (Jackie Shroff), an underworld crime lord who requested him to take care of his daughters and made him swear not to tell them that he was their actual father as he was in jail. Batook also reveals that he betrayed Nagre and planned to marry the girls to his three sons, the robbers who tried to steal the jewels. Unbeknownst to him, Nagre is out of prison and has arrived in London.

While the girls prepare a wax statue for Batook, the boys go into town, where some gangsters are teasing some girls. Suddenly, Nagre appears and attack the gangsters. After the gangsters run away, Nagre sees the boys, and ask why did not help. The boys claim that they were disabled. Bunty, who was in the wheelchair at the time, claims he was crippled. Sandy, holding Teddy's cane, claims he is blind, and that Teddy is mute. Later, Nagre goes to Batook's office and asks him about his daughters' future husbands. Batook says that while the girls' future husbands are disabled, he knows three normal men who are suitable for the daughters. Batook takes Nagre to a Gurdwara to see his sons, Rishi (Samir Kochhar), Rohan (Nikitin Dheer), and Rajeev (Aarav Chowdhary), claiming they are orphans who do community service. Nagre decides that the three are suitable for his daughters.

At Batook's house, Nagre claims that Batook owes him 50 million British Pounds. Nagre gives Batook and the boys 10 days to make up the money, or Ganga, Jamuna, and Saraswati must marry Rishi, Rohan, and Rajeev. During these 10 days, Nagre and his "sons" will also live in Batook's house, meaning that while in front of both Batook and Nagre, Sandy, Teddy, and Bunty must act as blind-disabled, mute-blind, and disabled-mute. Sandy, Teddy, and Bunty come up with a plan to get rid of Nagre's sons. During a St. Patrick's Day party, the girls get Rishi, Rohan, and Rajeev drunk. The next day, they tell each other that they had sex with their respective girls, only to find out that they had sex with the maids. The maids request compensation, or they will sue them. Nagre surrenders to his daughters' pleas of love.

The next day, the girls take Sandy, Teddy, and Bunty to church, asking for forgiveness. Saraswati, who takes care of disabled children, tells them that two boys were mocking a child because of his disability. The girls feel guilty because they felt that they were mocking people with disabilities by having the boys act as if they were blind, crippled, and mute. After this, the boys feel guilty, as they were only marrying the girls for money. They go to the warehouse area of Madame Tussauds to meet their girlfriends. They instead find Batook's sons, who explain that they found out the boys were normal. While Teddy and Bunty fight Batook's sons' gang members, Sandy has accidentally heard Teddy say "Indian", and Sundi, Sandy's alternate personality, tries to kill Sandy. Batook walks in announcing his arrival to his sons.

The boys blackmail Batook having overheard him, seeking that Nagre's fortune of 50 million is divided into 7 parts: Rishi, Rohan, Rajeev, Batook, Sandy, Teddy, and Bunty's shares. Sundi says to divide it into 8 shares, as Sandy/Sundi counts as two people. Aakhri Pasta arrives and demands his share.The three maids each demand two shares, one for them, and the other for their unborn children they are now carrying. Nagre then arrives and explains that he found the recording on Bunty's laptop revealing the boys' lies. Nagre also overheard Batook, telling his sons about his plan. Nagre then attempts to kill everyone in the warehouse, while the lights turn on and off. As the girls arrive, Rishi, Rohan, and Rajeev see them and hold them at knifepoint in front of Nagre. Sandy, Teddy, and Bunty then rush to save the girls, injuring themselves in the process. The girls forgive the boys and reconcile with Nagre after learning about their parentage.